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Usage Information

NPs — heart hormones that regulate brown fat?
Andrew J. Whittle, Antonio Vidal-Puig
Andrew J. Whittle, Antonio Vidal-Puig
Published February 6, 2012
Citation Information: J Clin Invest. 2012;122(3):804-807. https://doi.org/10.1172/JCI62595.
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Commentary

NPs — heart hormones that regulate brown fat?

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Abstract

Thermogenesis in brown adipose tissue (BAT) is well characterized as being under the control of the sympathetic nervous system. The energy-burning capacity of BAT makes it an attractive target for anti-obesity therapies. However, previous attempts to manipulate BAT’s sympathetic activation have lacked specificity. In this issue of the JCI, Bordicchia et al. provide new data indicating that cardiac natriuretic peptides (NPs) are also able to activate thermogenic machinery in adipose tissue. Their findings suggest a novel strategy to increase energy dissipation in adipose tissue, independent of adrenergic receptors.

Authors

Andrew J. Whittle, Antonio Vidal-Puig

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