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Usage Information

Alarmins: awaiting a clinical response
James K. Chan, … , Nicole Horwood, Jagdeep Nanchahal
James K. Chan, … , Nicole Horwood, Jagdeep Nanchahal
Published August 1, 2012
Citation Information: J Clin Invest. 2012;122(8):2711-2719. https://doi.org/10.1172/JCI62423.
View: Text | PDF
Science in Medicine

Alarmins: awaiting a clinical response

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Abstract

Alarmins are endogenous molecules that are constitutively available and released upon tissue damage and activate the immune system. Current evidence indicates that uncontrolled and excessive release of alarmins contributes to the dysregulated processes seen in many inflammatory and autoimmune conditions, as well as tumorigenesis and cancer spread. Conversely, alarmins have also been found to play a major role in the orchestration of tissue homeostasis, including repair and remodeling in the heart, skin, and nervous system. Here, we provide an update and overview on alarmins, highlighting the areas that may benefit from this clinical translation.

Authors

James K. Chan, Johannes Roth, Joost J. Oppenheim, Kevin J. Tracey, Thomas Vogl, Marc Feldmann, Nicole Horwood, Jagdeep Nanchahal

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 2,206 248
PDF 130 82
Figure 170 7
Table 163 0
Supplemental data 50 0
Citation downloads 86 0
Totals 2,805 337
Total Views 3,142
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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