Usage Information

DYRK1A in Down syndrome: an oncogene or tumor suppressor?
Yehudit Birger, Shai Izraeli
Yehudit Birger, Shai Izraeli
Published February 22, 2012
Citation Information: J Clin Invest. 2012;122(3):807-810. https://doi.org/10.1172/JCI62372.
View: Text | PDF
Commentary

DYRK1A in Down syndrome: an oncogene or tumor suppressor?

Abstract

Children with Down syndrome (DS) have a markedly increased risk of developing acute megakaryoblastic leukemia (AMKL) and acute lymphoblastic leukemia compared with that of children without DS. Despite recent breakthroughs, it is not clear which genes on chromosome 21, the chromosome that is trisomic in individuals with DS, cause this predisposition. In this issue of the JCI, Malinge et al. report their loss- and gain-of-function experiments in mouse and human cells that show that increased expression of the kinase encoded by the chromosome 21 gene DYRK1A suppresses the nuclear factor of activated T cells pathway and promotes AMKL. Interestingly, the same protein has been suggested to contribute to the reduced risk of epithelial cancers in adults with DS, leading to the possibility that it could be proleukemic in children and antitumorigenic in adults.

Authors

Yehudit Birger, Shai Izraeli

×

Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 443 40
PDF 65 20
Figure 125 2
Citation downloads 65 0
Totals 698 62
Total Views 760
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement