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Usage Information

Do MDL-1+ cells play a broad role in acute inflammation?
Peter A. Ward
Peter A. Ward
Published October 17, 2011
Citation Information: J Clin Invest. 2011;121(11):4234-4237. https://doi.org/10.1172/JCI60122.
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Commentary

Do MDL-1+ cells play a broad role in acute inflammation?

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Abstract

Dengue virus (DV) reacts with myeloid DAP12-associating lectin–1 (MDL-1) on immature polymorphonuclear leukocytes. Interaction of DV with MDL-1+ cells triggers systemic inflammatory response syndrome (SIRS) and dengue shock syndrome (DSS), with subsequent multi-organ failure. In this issue of the JCI, Cheung et al. find that sterile acute liver injury in mice is associated with the accumulation of MDL-1+ cells and that triggering of these cells by DV or an MDL-1–specific agonist antibody leads to SIRS, shock, and death. These findings may have broad mechanistic and therapeutic implications for the development of SIRS, sepsis, and shock in humans exposed to a wide array of infectious and non-infectious conditions.

Authors

Peter A. Ward

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