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Usage Information

Dietary nitrate, nitric oxide, and restenosis
John P. Cooke, Yohannes T. Ghebremariam
John P. Cooke, Yohannes T. Ghebremariam
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Commentary

Dietary nitrate, nitric oxide, and restenosis

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Abstract

Endothelium-derived NO controls the contractility and growth state of the underlying vascular smooth muscle cells and regulates the interaction of the vessel wall with circulating blood elements. Acute injury of the vessel wall denudes the endothelial lining, removing homeostatic regulation and precipitating a wave of events leading to myointimal hyperplasia. In this issue of the JCI, Alef and colleagues provide evidence that in the injured vessel wall, the disruption of the NOS pathway is countered by induction of xanthine oxidoreductase, an enzyme capable of producing NO from nitrite. In addition, they link low dietary nitrite levels to increased severity of myointimal hyperplasia following vessel injury in mice.

Authors

John P. Cooke, Yohannes T. Ghebremariam

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Usage data is cumulative from July 2025 through July 2026.

Usage JCI PMC
Text version 545 15
PDF 170 3
Figure 187 0
Citation downloads 143 0
Totals 1,045 18
Total Views 1,063
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