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Usage Information

Recent advances in the molecular pathophysiology of atrial fibrillation
Reza Wakili, … , Dobromir Dobrev, Stanley Nattel
Reza Wakili, … , Dobromir Dobrev, Stanley Nattel
Published August 1, 2011
Citation Information: J Clin Invest. 2011;121(8):2955-2968. https://doi.org/10.1172/JCI46315.
View: Text | PDF
Science in Medicine

Recent advances in the molecular pathophysiology of atrial fibrillation

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Abstract

Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes substantial morbidity and contributes to mortality. The mechanisms underlying AF are complex, involving both increased spontaneous ectopic firing of atrial cells and impulse reentry through atrial tissue. Over the past ten years, there has been enormous progress in understanding the underlying molecular pathobiology. This article reviews the basic mechanisms and molecular processes causing AF. We discuss the ways in which cardiac disease states, extracardiac factors, and abnormal genetic control lead to the arrhythmia. We conclude with a discussion of the potential therapeutic implications that might arise from an improved mechanistic understanding.

Authors

Reza Wakili, Niels Voigt, Stefan Kääb, Dobromir Dobrev, Stanley Nattel

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 2,607 443
PDF 231 85
Figure 918 16
Citation downloads 98 0
Totals 3,854 544
Total Views 4,398
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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