Cellular pathophysiology of ischemic acute kidney injury
Joseph V. Bonventre, Li Yang
Joseph V. Bonventre, Li Yang
Published November 1, 2011
Citation Information: J Clin Invest. 2011;121(11):4210-4221. https://doi.org/10.1172/JCI45161.
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Science in Medicine

Cellular pathophysiology of ischemic acute kidney injury

Abstract

Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here, we review the major components of this dynamic process, which involves hemodynamic alterations, inflammation, and endothelial and epithelial cell injury, followed by repair that can be adaptive and restore epithelial integrity or maladaptive, leading to chronic kidney disease. Better understanding of the cellular pathophysiological processes underlying kidney injury and repair will hopefully result in the design of more targeted therapies to prevent the injury, hasten repair, and minimize chronic progressive kidney disease.

Authors

Joseph V. Bonventre, Li Yang

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Figure 1

Causes of reduction in generalized or regional renal blood flow (RBF).

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Causes of reduction in generalized or regional renal blood flow (RBF). V...
Various pathophysiological states and medications can contribute to reduction of RBF, causing generalized or localized ischemia to the kidney leading to AKI. This figure represents a partial list and points to ischemia as being a common pathway in a variety of clinical states affecting the kidney.