Usage Information

Semaphorin 3E, an exception to the rule
Michael Klagsbrun, Akio Shimizu
Michael Klagsbrun, Akio Shimizu
Published July 26, 2010
Citation Information: J Clin Invest. 2010;120(8):2658-2660. https://doi.org/10.1172/JCI44110.
View: Text | PDF
Commentary

Semaphorin 3E, an exception to the rule

Abstract

Class 3 semaphorins (Sema3s) regulate axon guidance, angiogenesis, tumor growth, and tumor metastasis. Neuropilins (NRPs; NRP1 and NRP2) are the cell surface receptors for the Sema3s. However, to signal, interaction of Sema3s and NRPs with plexins is obligatory. In this issue of the JCI, Casazza and colleagues report data that challenge the conventional wisdom about the role of Sema3s in tumor metastasis. As a rule, Sema3B and Sema3F, for example, are inhibitors of tumor angiogenesis, progression, and metastasis. However, Casazza et al. found that Sema3E inhibited tumor growth but atypically promoted invasiveness and metastasis. This metastatic potential was dependent on Plexin D1 expression but was independent of NRP expression. Of clinical importance, Sema3E and Plexin D1 were found to be upregulated in human colon cancer, liver metastasis, and melanoma progression.

Authors

Michael Klagsbrun, Akio Shimizu

×

Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 474 35
PDF 61 19
Figure 50 1
Table 40 0
Citation downloads 62 0
Totals 687 55
Total Views 742
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement