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Usage Information

Semaphorin 3E, an exception to the rule
Michael Klagsbrun, Akio Shimizu
Michael Klagsbrun, Akio Shimizu
Published July 26, 2010
Citation Information: J Clin Invest. 2010;120(8):2658-2660. https://doi.org/10.1172/JCI44110.
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Commentary

Semaphorin 3E, an exception to the rule

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Abstract

Class 3 semaphorins (Sema3s) regulate axon guidance, angiogenesis, tumor growth, and tumor metastasis. Neuropilins (NRPs; NRP1 and NRP2) are the cell surface receptors for the Sema3s. However, to signal, interaction of Sema3s and NRPs with plexins is obligatory. In this issue of the JCI, Casazza and colleagues report data that challenge the conventional wisdom about the role of Sema3s in tumor metastasis. As a rule, Sema3B and Sema3F, for example, are inhibitors of tumor angiogenesis, progression, and metastasis. However, Casazza et al. found that Sema3E inhibited tumor growth but atypically promoted invasiveness and metastasis. This metastatic potential was dependent on Plexin D1 expression but was independent of NRP expression. Of clinical importance, Sema3E and Plexin D1 were found to be upregulated in human colon cancer, liver metastasis, and melanoma progression.

Authors

Michael Klagsbrun, Akio Shimizu

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Usage data is cumulative from February 2020 through February 2021.

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PDF 17 45
Figure 33 0
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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