A look at autoimmunity and inflammation in the eye
Rachel R. Caspi
Rachel R. Caspi
Published September 1, 2010
Citation Information: J Clin Invest. 2010;120(9):3073-3083. https://doi.org/10.1172/JCI42440.
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Review

A look at autoimmunity and inflammation in the eye

Abstract

Autoimmune and inflammatory uveitis are a group of potentially blinding intraocular inflammatory diseases that arise without a known infectious trigger and are often associated with immunological responses to unique retinal proteins. In the United States, about 10% of the cases of severe visual handicap are attributed to this group of disorders. As I discuss here, experimental models of ocular autoimmunity targeting retinal proteins have brought about a better understanding of the basic immunological mechanisms involved in the pathogenesis of uveitis and are serving as templates for the development of novel therapies.

Authors

Rachel R. Caspi

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Figure 2

Clinical and histological appearance of uveitis: human and mouse.

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Clinical and histological appearance of uveitis: human and mouse. (A) Ap...
(A) Appearance of the fundus (posterior pole of the eye) and retinal histology (original magnification, ×200) of a healthy human retina and those from a patient with uveitis. Images provided by Chi-Chao Chan, National Eye Institute, NIH. (B) Fundus (×20) and retinal histology (×400) of a B10.RIII mouse immunized with IRBP. Lower-right panels of A and B reproduced with permission from Immunological Reviews (24).