Usage Information

Putting the brakes on BTLA in T cell–mediated cancer immunotherapy
Chrystal M. Paulos, Carl H. June
Chrystal M. Paulos, Carl H. June
Published December 28, 2009
Citation Information: J Clin Invest. 2010;120(1):76-80. https://doi.org/10.1172/JCI41811.
View: Text | PDF
Commentary

Putting the brakes on BTLA in T cell–mediated cancer immunotherapy

Abstract

Attenuating coinhibitory molecules for the treatment of cancer is gaining a great deal of attention as a strategy for immunotherapy. The B and T lymphocyte attenuator (BTLA, CD272) is a novel coinhibitory molecule structurally and functionally related to CTLA-4 and PD-1. A study in this issue of the JCI by Derré et al. reveals that BTLA is expressed on virus-specific human CD8+ T cells but is progressively downregulated after their differentiation from a naive to effector phenotype (see the related article beginning on page 157). Surprisingly, tumor-specific human CD8+ T cells continue to express BTLA even after their differentiation to an effector phenotype. Remarkably, vaccination of melanoma patients with CpG led to BTLA downregulation on tumor-specific human CD8+ T cells, concomitant with restoration of their functionality. We discuss these findings in the context of the expanding field of cosignaling molecules and their implications for T cell–based therapies for cancer.

Authors

Chrystal M. Paulos, Carl H. June

×

Usage data is cumulative from November 2024 through November 2025.

Usage JCI PMC
Text version 549 42
PDF 86 19
Figure 175 3
Citation downloads 70 0
Totals 880 64
Total Views 944
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement