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Usage Information

Pathogenic antibodies are active participants in spinal cord injury
Gregory A. Dekaban, Sakina Thawer
Gregory A. Dekaban, Sakina Thawer
Published September 21, 2009
Citation Information: J Clin Invest. 2009;119(10):2881-2884. https://doi.org/10.1172/JCI40839.
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Commentary

Pathogenic antibodies are active participants in spinal cord injury

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Abstract

The role of B cells and autoimmunity as contributing factors to poor neurological outcomes following spinal cord injury (SCI) is poorly understood. The study by Ankeny et al., in this issue of the JCI, identifies a new immunopathological mechanism arising after SCI in mice (see the related article beginning on page 2990). The study shows that B cells produce pathogenic antibodies that impair lesion repair, resulting in worse neurological outcome. This new understanding of SCI disease pathogenesis, if confirmed in humans, reveals potential avenues for the development of novel neuroprotective immunotherapies.

Authors

Gregory A. Dekaban, Sakina Thawer

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