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Usage Information

Inflammasomes: too big to miss
Andrea Stutz, … , Douglas T. Golenbock, Eicke Latz
Andrea Stutz, … , Douglas T. Golenbock, Eicke Latz
Published December 1, 2009
Citation Information: J Clin Invest. 2009;119(12):3502-3511. https://doi.org/10.1172/JCI40599.
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Science in Medicine

Inflammasomes: too big to miss

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Abstract

Inflammation is the coordinated immune response to harmful stimuli that appear during infections or after tissue damage. Cells of the innate immune system are the central players in mediating inflammatory tissue responses. These cells are equipped with an array of signaling receptors that detect foreign molecular substances or altered endogenous molecules that appear under situations of stress. This review provides an overview of recent progress in elucidating the molecular mechanisms that lead to inflammatory reactions. We discuss the current knowledge of the mechanisms leading to the activation of cytoplasmic, multimolecular protein complexes, termed “inflammasomes,” which regulate the activity of caspase-1 and the maturation and release of IL-1β.

Authors

Andrea Stutz, Douglas T. Golenbock, Eicke Latz

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Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 1,114 136
PDF 81 24
Figure 216 1
Table 67 0
Citation downloads 81 0
Totals 1,559 161
Total Views 1,720
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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