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Usage Information

Anticancer therapy: boosting the bang of Bim
Andrea Wahner Hendrickson, Xue Wei Meng, Scott H. Kaufmann
Andrea Wahner Hendrickson, Xue Wei Meng, Scott H. Kaufmann
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Anticancer therapy: boosting the bang of Bim

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Abstract

Even though activating mutations of B-Raf, a kinase atop the MAPK signaling cascade, reportedly sensitize tumor cells to MEK inhibitors, Raf and MEK inhibitors have exhibited limited clinical activity. In this issue of the JCI, Cragg et al. report that MEK inhibition upregulates the proapoptotic Bcl-2 family member Bim but induces little regression of human melanoma xenografts in mice unless the Bcl-2 antagonist ABT-737 is added (see the related article beginning on page 3651). These findings illustrate the potential benefit of simultaneously inhibiting oncogenic kinases and inhibiting Bcl-2 action in solid tumors.

Authors

Andrea Wahner Hendrickson, Xue Wei Meng, Scott H. Kaufmann

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Usage data is cumulative from August 2025 through August 2026.

Usage JCI PMC
Text version 495 8
PDF 184 7
Figure 145 0
Citation downloads 187 0
Totals 1,011 15
Total Views 1,026
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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