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Usage Information

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
Catherine Postic, Jean Girard
Catherine Postic, Jean Girard
Published March 3, 2008
Citation Information: J Clin Invest. 2008;118(3):829-838. https://doi.org/10.1172/JCI34275.
View: Text | PDF
Science in Medicine

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

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Abstract

Nonalcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance, and type 2 diabetes. NAFLD represents a large spectrum of diseases ranging from (i) fatty liver (hepatic steatosis); (ii) steatosis with inflammation and necrosis; and (iii) cirrhosis. Although the molecular mechanism leading to the development of hepatic steatosis in the pathogenesis of NAFLD is complex, recent animal models have shown that modulating important enzymes in fatty acid synthesis in liver may be key for the treatment of NAFLD. This review discusses recent advances in the field.

Authors

Catherine Postic, Jean Girard

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Usage data is cumulative from August 2024 through August 2025.

Usage JCI PMC
Text version 2,171 321
PDF 164 87
Figure 553 6
Citation downloads 101 0
Totals 2,989 414
Total Views 3,403
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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