Go to
JCI Insight
Abstract
MicroRNAs act as negative regulators of gene expression by inhibiting the translation or promoting the degradation of target mRNAs. Recent studies have revealed key roles of microRNAs as regulators of the growth, development, function, and stress responsiveness of the heart, providing glimpses of undiscovered regulatory mechanisms and potential therapeutic targets for the treatment of heart disease.
Authors
Eva van Rooij, Eric N. Olson
Figure 2
Induction of cardiac hypertrophy and heart failure by miR-195.
Options:
View larger image
(or click on image)
Download as PowerPoint
H&E sections of 2-week-old wild-type and transgenic mice expressing miR-195 under control of the αMHC promoter. In transgenic as compared with wild-type mice, moderate levels of miR-195 expression (26-fold) cause cardiac hypertrophy, and higher levels of expression (29-fold) cause dilated cardiomyopathy with ventricular dilatation and wall thinning. Reproduced with permission from Proceedings of the National Academy of Sciences of the United States of America (8 ). Scale bar: 2 mm.
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)