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Usage Information

Prime suspect: the TCF7L2 gene and type 2 diabetes risk
Andrew T. Hattersley
Andrew T. Hattersley
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Commentary

Prime suspect: the TCF7L2 gene and type 2 diabetes risk

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Abstract

Transcription factor-7–like 2 (TCF7L2) is the most important type 2 diabetes susceptibility gene identified to date, with common intronic variants strongly associated with diabetes in all major racial groups. This ubiquitous transcription factor in the Wnt signaling pathway was not previously known to be involved in glucose homeostasis, so defining the underlying mechanism(s) will provide new insights into diabetes. In this issue of the JCI, Lyssenko and colleagues report on their human and isolated islet studies and suggest that the risk allele increases TCF7L2 expression in the pancreatic β cell, reducing insulin secretion and hence predisposing the individual to diabetes (see the related article beginning on page 2155).

Authors

Andrew T. Hattersley

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Usage data is cumulative from December 2024 through December 2025.

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Figure 263 1
Citation downloads 214 0
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Total Views 2,829
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ISSN: 0021-9738 (print), 1558-8238 (online)

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