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Usage Information

Unchecked thrombin is bad news for troubled arteries
Eric Camerer
Eric Camerer
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Commentary

Unchecked thrombin is bad news for troubled arteries

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Abstract

Thrombin is clearly a key trigger of thrombosis, the proximal cause of most morbidity and mortality in atherosclerotic cardiovascular disease. Might thrombin also contribute to longer-term, structural changes in the arterial wall that promote narrowing and clotting? A study in this issue of the JCI argues that it can. Aihara et al. report that haploinsufficiency of heparin cofactor II, a glycosaminoglycan-dependent thrombin inhibitor, exacerbates injury- or hyperlipidemia-induced arterial lesion formation in mice, possibly by excessive thrombin signaling through protease-activated receptors (see the related article beginning on page 1514).

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Eric Camerer

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Usage data is cumulative from December 2024 through December 2025.

Usage JCI PMC
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PDF 72 15
Figure 118 1
Citation downloads 88 0
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Total Views 527

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