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Usage Information

HIF-1 and HIF-2: working alone or together in hypoxia?
Peter J. Ratcliffe
Peter J. Ratcliffe
Published April 2, 2007
Citation Information: J Clin Invest. 2007;117(4):862-865. https://doi.org/10.1172/JCI31750.
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Commentary

HIF-1 and HIF-2: working alone or together in hypoxia?

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Abstract

Erythropoietin (EPO) is the hormonal regulator of red cell production and provided the paradigm for oxygen-regulated gene expression that led to the discovery of hypoxia-inducible factor (HIF). In this issue of the JCI, Rankin and colleagues show, using targeted gene inactivation, that induction of Epo expression in murine liver is dependent on the integrity of HIF-2α, and not HIF-1α (see the related article beginning on page 1068). These results demonstrate distinct functions for different HIF-α isoforms that could potentially be exploited in therapeutic approaches to anemia.

Authors

Peter J. Ratcliffe

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Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 1,041 793
PDF 98 82
Figure 192 3
Citation downloads 78 0
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Total Views 2,287
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