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Usage Information

Hypoglycemia, functional brain failure, and brain death
Philip E. Cryer
Philip E. Cryer
Published April 2, 2007
Citation Information: J Clin Invest. 2007;117(4):868-870. https://doi.org/10.1172/JCI31669.
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Commentary

Hypoglycemia, functional brain failure, and brain death

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Abstract

Hypoglycemia commonly causes brain fuel deprivation, resulting in functional brain failure, which can be corrected by raising plasma glucose concentrations. Rarely, profound hypoglycemia causes brain death that is not the result of fuel deprivation per se. In this issue of the JCI, Suh and colleagues use cell culture and in vivo rodent studies of glucose deprivation and marked hypoglycemia and provide evidence that hypoglycemic brain neuronal death is in fact increased by neuronal NADPH oxidase activation during glucose reperfusion (see the related article beginning on page 910). This finding suggests that, at least in the setting of profound hypoglycemia, therapeutic hyperglycemia should be avoided.

Authors

Philip E. Cryer

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Usage data is cumulative from August 2024 through August 2025.

Usage JCI PMC
Text version 1,698 36,419
PDF 290 352
Figure 164 19
Citation downloads 122 0
Totals 2,274 36,790
Total Views 39,064
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