Molecular regulation of HDL metabolism and function: implications for novel therapies
Daniel J. Rader
Daniel J. Rader
Published December 1, 2006
Citation Information: J Clin Invest. 2006;116(12):3090-3100. https://doi.org/10.1172/JCI30163.
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Science in Medicine

Molecular regulation of HDL metabolism and function: implications for novel therapies

Abstract

HDL metabolism represents a major target for the development of therapies intended to reduce the risk of atherosclerotic cardiovascular disease. HDL metabolism is complex and involves dissociation of HDL apolipoprotein and HDL cholesterol metabolism. Advances in our understanding of the molecular regulation of HDL metabolism, macrophage cholesterol efflux, and HDL function will lead to a variety of novel therapeutics.

Authors

Daniel J. Rader

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Figure 3

Pathways of apoA-I catabolism.

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Pathways of apoA-I catabolism. Lipid-poor apoA-I can be filtered through...
Lipid-poor apoA-I can be filtered through the renal glomerulus and be degraded by the renal tubular cell via the cubulin-megalin pathway. Lipid-poor apoA-I is generated by the action of lipases such as HL and EL on mature HDL, and the action of these lipases is enhanced by the CETP-mediated transfer of TG into HDL. Mature HDL can also be catabolized by the hepatocyte through binding of HDL-apoE to hepatic receptors or through a poorly characterized mechanism of direct interaction with the hepatocyte. AMN, amnionless.