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Usage Information

Toll-like receptors and IFN-α: partners in autoimmunity
Marco Colonna
Marco Colonna
Published September 1, 2006
Citation Information: J Clin Invest. 2006;116(9):2319-2322. https://doi.org/10.1172/JCI29879.
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Commentary

Toll-like receptors and IFN-α: partners in autoimmunity

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Abstract

Many autoimmune diseases are thought to be precipitated by viral infections. In this issue of the JCI, Lang et al. demonstrate that, in a mouse model of autoimmune hepatitis, viral infections not only trigger expansion of self-reactive T cells but also activate antigen-presenting cells through TLR stimulation (see the related article beginning on page 2456). Activated cells then secrete IFN-α and TNF-α, which trigger tissue release of chemokines that attract self-reactive CD8+ T cells, ultimately leading to liver damage.

Authors

Marco Colonna

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Usage data is cumulative from May 2024 through May 2025.

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Figure 57 1
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