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Usage Information

Of mice, men, and elephants:Mycobacterium tuberculosis cell envelope lipids and pathogenesis
Lee W. Riley
Lee W. Riley
Published June 1, 2006
Citation Information: J Clin Invest. 2006;116(6):1475-1478. https://doi.org/10.1172/JCI28734.
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Commentary

Of mice, men, and elephants:Mycobacterium tuberculosis cell envelope lipids and pathogenesis

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Abstract

Mycolic acids and structures attached to them constitute a major part of the protective envelope of Mycobacterium tuberculosis, and for this reason, their role in tuberculosis pathogenesis has been extensively studied. In this issue of the JCI, Rao et al. examine the effect of trans-cyclopropanation of oxygenated mycolic acids attached to trehalose dimycolate (TDM) on the murine immune response to infection (see the related article beginning on page 1660). Surprisingly, they found that an M. tuberculosis mutant lacking trans-cyclopropane rings was hypervirulent in mice. The recent recognition of a hypervirulence phenotype in mice associated with laboratory and clinical M. tuberculosis strains with altered cell wall components has provided new insights into how M. tuberculosis may establish persistent infection. However, to date, characterization of these bioactive products in pathogenesis has been largely reductionistic; the relationship of their effects observed in mice to the persistent infection and tuberculosis caused by M. tuberculosis observed in humans remains obscure.

Authors

Lee W. Riley

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Usage data is cumulative from June 2024 through June 2025.

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PDF 71 11
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