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Usage Information

Gastrointestinal motility and glycemic control in diabetes: the chicken and the egg revisited?
Christopher K. Rayner, Michael Horowitz
Christopher K. Rayner, Michael Horowitz
Published February 1, 2006
Citation Information: J Clin Invest. 2006;116(2):299-302. https://doi.org/10.1172/JCI27758.
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Commentary

Gastrointestinal motility and glycemic control in diabetes: the chicken and the egg revisited?

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Abstract

Upper gastrointestinal dysfunction occurs frequently in diabetes and potentially contributes to both abdominal symptoms and impaired glycemic control; conversely, variations in blood glucose concentration reversibly affect gut motility in humans. In this issue of the JCI, Anitha et al. report apoptosis of rodent enteric neurons under hyperglycemic conditions, both in vitro and in vivo, associated with impaired PI3K activity and preventable by glial cell line–derived neurotrophic factor. These observations add to recent insights gained from animal models regarding the etiology of diabetic gastrointestinal dysfunction, but investigators must strive to translate animal data to human diabetes.

Authors

Christopher K. Rayner, Michael Horowitz

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Usage data is cumulative from November 2024 through November 2025.

Usage JCI PMC
Text version 728 248
PDF 86 11
Figure 95 2
Citation downloads 70 0
Totals 979 261
Total Views 1,240
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