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Usage Information

Inflammation, stress, and diabetes
Kathryn E. Wellen, Gökhan S. Hotamisligil
Kathryn E. Wellen, Gökhan S. Hotamisligil
Published May 2, 2005
Citation Information: J Clin Invest. 2005;115(5):1111-1119. https://doi.org/10.1172/JCI25102.
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Review

Inflammation, stress, and diabetes

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Abstract

Over the last decade, an abundance of evidence has emerged demonstrating a close link between metabolism and immunity. It is now clear that obesity is associated with a state of chronic low-level inflammation. In this article, we discuss the molecular and cellular underpinnings of obesity-induced inflammation and the signaling pathways at the intersection of metabolism and inflammation that contribute to diabetes. We also consider mechanisms through which the inflammatory response may be initiated and discuss the reasons for the inflammatory response in obesity. We put forth for consideration some hypotheses regarding important unanswered questions in the field and suggest a model for the integration of inflammatory and metabolic pathways in metabolic disease.

Authors

Kathryn E. Wellen, Gökhan S. Hotamisligil

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 5,311 1,857
PDF 344 230
Figure 436 7
Table 119 0
Supplemental data 77 1
Citation downloads 191 0
Totals 6,478 2,095
Total Views 8,573
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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