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Usage Information

Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease
Shinji Tamura, Iichiro Shimomura
Shinji Tamura, Iichiro Shimomura
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Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease

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Abstract

Nonalcoholic fatty liver disease (NAFLD) is a component of the metabolic syndrome, with a clinical spectrum ranging from simple fatty liver to steatohepatitis, cirrhosis, and hepatocellular carcinoma. The primary event of NAFLD is the accumulation of triacylglycerols (TAGs) in hepatocytes. In this issue of the JCI, Donnelly et al. report on their use of stable isotope methodology to show that fatty acids stored in adipose tissue and fatty acids newly made within the liver through de novo lipogenesis are the major sources of TAGs in the liver and are secreted as lipoproteins in NAFLD.

Authors

Shinji Tamura, Iichiro Shimomura

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Usage data is cumulative from September 2025 through September 2026.

Usage JCI PMC
Text version 1,591 203
PDF 344 26
Figure 266 0
Citation downloads 295 0
Totals 2,496 229
Total Views 2,725
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ISSN: 0021-9738 (print), 1558-8238 (online)

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