Usage Information

Ikaros transcription factors: flying between stress and inflammation
George P. Chrousos, Tomoshige Kino
George P. Chrousos, Tomoshige Kino
Published April 1, 2005
Citation Information: J Clin Invest. 2005;115(4):844-848. https://doi.org/10.1172/JCI24886.
View: Text | PDF
Commentary

Ikaros transcription factors: flying between stress and inflammation

Abstract

The hypothalamic-pituitary-adrenal axis (a major component of the stress system) and the immune system contribute to the maintenance of homeostasis at rest and during stress. Because of their essential roles for the survival of self and species, the activities of these systems have evolutionarily developed in parallel and are intertwined at many levels. In this issue of the JCI, Ezzat et al. demonstrate that Ikaros, a differentiation factor of leukocyte lineage, also influences the maturation of the fetal pituitary corticotroph and, hence, the secretion of adrenocorticotropic hormone before and after birth. These results indicate that Ikaros is an ontogenetic and phylogenetic integrator of the stress and immune systems and that abnormalities in its function may produce endocrine and/or immune pathologies.

Authors

George P. Chrousos, Tomoshige Kino

×

Usage data is cumulative from September 2024 through September 2025.

Usage JCI PMC
Text version 301 29
PDF 51 6
Figure 123 2
Table 24 0
Citation downloads 40 0
Totals 539 37
Total Views 576
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement