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Usage Information

TB, or not TB: that is the question – does TLR signaling hold the answer?
Terence M. Doherty, Moshe Arditi
Terence M. Doherty, Moshe Arditi
Published December 15, 2004
Citation Information: J Clin Invest. 2004;114(12):1699-1703. https://doi.org/10.1172/JCI23867.
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Commentary

TB, or not TB: that is the question – does TLR signaling hold the answer?

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Abstract

Innate immunity critically depends on signaling by Toll-like receptors (TLRs) that rely heavily on an intracellular adapter protein called myeloid differentiation factor 88 (MyD88). Adaptive immune defenses are generally thought to be orchestrated by innate immune responses and so should require intact TLR-MyD88 signaling pathways. But a surprising new study in MyD88-null mice infected with Mycobacterium tuberculosis challenges this view and instead suggests that MyD88 may not be absolutely required for a normal adaptive immune response.

Authors

Terence M. Doherty, Moshe Arditi

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Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 688 9
PDF 67 11
Figure 218 5
Citation downloads 81 0
Totals 1,054 25
Total Views 1,079
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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