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Usage Information

p16 and ARF: activation of teenage proteins in old age
Ande Satyanarayana, K. Lenhard Rudolph
Ande Satyanarayana, K. Lenhard Rudolph
Published November 1, 2004
Citation Information: J Clin Invest. 2004;114(9):1237-1240. https://doi.org/10.1172/JCI23437.
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Commentary

p16 and ARF: activation of teenage proteins in old age

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Abstract

Cellular senescence induced by different stresses and telomere shortening appears to play an important role in the aging process. The products of the INK4a/ARF locus — p16INK4a and ARF — arrest cell proliferation at the senescence stage by exerting their effects on retinoblastoma protein– and p53-mediated responsive pathways. A study in this issue of the JCI provides experimental evidence of a specific upregulation of these cell cycle inhibitors in a variety of organs during mammalian aging.

Authors

Ande Satyanarayana, K. Lenhard Rudolph

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Figure 96 1
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