Endothelial cell culture: beginnings of modern vascular biology
Ralph L. Nachman, Eric A. Jaffe
Ralph L. Nachman, Eric A. Jaffe
Published October 15, 2004
Citation Information: J Clin Invest. 2004;114(8):1037-1040. https://doi.org/10.1172/JCI23284.
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Retrospectives

Endothelial cell culture: beginnings of modern vascular biology

Abstract

Endothelial cells derived from human umbilical veins were first successfully cultured in vitro in 1973. Weibel-Palade bodies and the von Willebrand factor antigen were used as morphological, immunohistochemical, and functional markers to unequivocally identify the cells. These landmark studies helped initiate the growth of modern vascular biology.

Authors

Ralph L. Nachman, Eric A. Jaffe

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Figure 1

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Summary slide presented at the plenary session of the 1974 ASCI annual m...
Summary slide presented at the plenary session of the 1974 ASCI annual meeting in Atlantic City showing the first cultured endothelial cells and the criteria used to identify them.