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Abstract
The production of protective neutralizing antibodies occurs quickly in some viral infections but very slowly in others. In a new study, surface glycoproteins (the targets of neutralization) of 2 different viruses were genetically switched. Analysis of the neutralizing antibody response to each of the 2 parent and recombinant viruses in infected mice revealed that the speed of neutralizing antibody induction was intrinsically dependent on the surface glycoprotein and not the rest of the virus.
Authors
Eva Szomolanyi-Tsuda, Raymond M. Welsh
Figure 1
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Kinetics of neutralizing antibody responses induced in mice following infection with (A ) VSV, a bullet-shaped rhabdovirus containing one RNA species and (B ) LCMV, an arenavirus containing 2 virion RNAs and some ribosomes. By reverse genetic techniques, the virion surface glycoproteins were swapped between the two viruses (C and D ), and the rapidity in generating neutralizing antibodies was found to correlate with the surface glycoprotein expressed on the recombinant virus (10 ).
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ISSN: 0021-9738 (print), 1558-8238 (online)