Pulmonary fibrosis: thinking outside of the lung
Stavros Garantziotis, … , Mark P. Steele, David A. Schwartz
Stavros Garantziotis, … , Mark P. Steele, David A. Schwartz
Published August 1, 2004
Citation Information: J Clin Invest. 2004;114(3):319-321. https://doi.org/10.1172/JCI22497.
View: Text | PDF
Commentary

Pulmonary fibrosis: thinking outside of the lung

Abstract

Pulmonary fibrosis is a devastating condition that leads to progressive lung destruction and scarring. Previous mechanistic research has focused on the local fibroproliferative process in the lung. However, emerging evidence suggests that circulating cells of hematopoietic origin play a crucial role in the pathogenesis of this disease .

Authors

Stavros Garantziotis, Mark P. Steele, David A. Schwartz

×

Figure 1

Options: View larger image (or click on image) Download as PowerPoint
Proposed mechanism for the pathogenesis of pulmonary fibrosis. The lung ...
Proposed mechanism for the pathogenesis of pulmonary fibrosis. The lung is naturally exposed to repetitive injury from a variety of exogenous and endogenous stimuli. Several local and systemic factors (e.g., fibroblasts, circulating fibrocytes, chemokines, growth factors, and clotting factors) contribute to tissue healing and functional recovery. Dysregulation of this intricate network through genetic predisposition, autoimmune conditions, or superimposed diseases can lead to aberrant wound healing with the result of pulmonary fibrosis. Alternatively, excessive injury to the lung may overwhelm even intact reparative mechanisms and lead to pulmonary fibrosis. The figure was adapted with permission from the New England Journal of Medicine (1).