Innate immunity dictates cytokine polarization relevant to the development of pulmonary fibrosis
Robert M. Strieter, Michael P. Keane
Robert M. Strieter, Michael P. Keane
View: Text | PDF
Commentary

Innate immunity dictates cytokine polarization relevant to the development of pulmonary fibrosis

Abstract

New data support the importance of the innate immune response in the resolution or progression of pulmonary fibrosis. The presence of CXC chemokine receptor 3–expressing cells, specifically pulmonary NK cells, is necessary to produce IFN-γ. This is critical in the polarization of the immune response to injury toward a favorable Th1 response and resolution. In contrast, a Th2 response is associated with progressive fibrosis.

Authors

Robert M. Strieter, Michael P. Keane

×

Figure 1

Options: View larger image (or click on image) Download as PowerPoint
Polarization of the inflammatory response in pulmonary fibrosis. (A) Pol...
Polarization of the inflammatory response in pulmonary fibrosis. (A) Polarization of the immune response to injury is critical in dictating the ultimate response to that injury. (B) A type 1 response (i.e., cell-mediated immunity) leads to resolution. (C) In contrast, a type 2 response (i.e., humoral-mediated immunity) is associated with progressive fibrosis. CCL1, CC chemokine ligand 1; CXCL9, CXC chemokine ligand 9.