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Usage Information

Coagulation-dependent mechanisms and asthma
Michael A. Matthay, John A. Clements
Michael A. Matthay, John A. Clements
Published July 1, 2004
Citation Information: J Clin Invest. 2004;114(1):20-23. https://doi.org/10.1172/JCI22288.
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Commentary

Coagulation-dependent mechanisms and asthma

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Abstract

In several clinical disorders, there are interactions between inflammation-dependent tissue injury and thrombin formation, fibrin deposition, and impaired fibrinolysis. New evidence generated from a mouse model of allergic airway hyperreactivity suggests that disordered coagulation and fibrinolysis may contribute to the pathogenesis of asthma . The inflammatory mechanisms that lead to airway smooth muscle contraction and airway hyperresponsiveness may be associated with accumulation of extravascular fibrin, plasma exudates, and inflammatory cells that can lead to airway closure.

Authors

Michael A. Matthay, John A. Clements

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Usage data is cumulative from August 2024 through August 2025.

Usage JCI PMC
Text version 380 42
PDF 74 18
Figure 172 2
Citation downloads 71 0
Totals 697 62
Total Views 759
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