Anti–β₁-adrenergic receptor antibodies and heart failure: causation, not just correlation

• Text
• PDF

Abstract

Antibodies specific for the β1-adrenergic receptor are found in patients with chronic heart failure of various etiologies. From work presented in this issue of the JCI, we can now infer that these antibodies actually contribute to the pathogenesis of chronic heart failure. This commentary discusses mechanisms by which these antibodies may engender cardiomyopathy.

Authors

Neil J. Freedman, Robert J. Lefkowitz