Salt handling and hypertension
Kevin M. O’Shaughnessy, Fiona E. Karet
Kevin M. O’Shaughnessy, Fiona E. Karet
Published April 15, 2004
Citation Information: J Clin Invest. 2004;113(8):1075-1081. https://doi.org/10.1172/JCI21560.
View: Text | PDF
Science in Medicine

Salt handling and hypertension

Abstract

The kidney plays a central role in our ability to maintain appropriate sodium balance, which is critical to determination of blood pressure. In this review we outline current knowledge of renal salt handling at the molecular level, and, given that Westernized societies consume more salt than is required for normal physiology, we examine evidence that the lowering of salt intake can combat hypertension.

Authors

Kevin M. O’Shaughnessy, Fiona E. Karet

×

Figure 3

Options: View larger image (or click on image) Download as PowerPoint
BP changes during the DASH-Sodium trial. Although arrows are unidirectio...
BP changes during the DASH-Sodium trial. Although arrows are unidirectional, the order in which individuals were assigned a given salt level was random with a crossover design. The numbers next to the lines connecting the data points are the mean changes in BP. The 95% confidence intervals are given in parentheses. *P < 0.05, †P < 0.01, and #P < 0.001; symbols indicate significant differences in BP between groups or between dietary sodium categories. Reproduced with permission from the New England Journal of Medicine (54).