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Usage Information

Insig: a significant integrator of nutrient and hormonal signals
Alan D. Attie
Alan D. Attie
Published April 15, 2004
Citation Information: J Clin Invest. 2004;113(8):1112-1114. https://doi.org/10.1172/JCI21450.
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Category: Commentary

Insig: a significant integrator of nutrient and hormonal signals

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Abstract

Lipogenesis is regulated by sterols and by insulin through the regulated expression and activation of the sterol regulatory element–binding proteins (SREBPs). A new study shows one way in which sterol and insulin regulation can be decoupled. In transgenic mice overexpressing a protein that regulates SREBP activation, lipogenesis is more sensitive to cholesterol and less sensitive to insulin.

Authors

Alan D. Attie

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