Human African trypanosomiasis of the CNS: current issues and challenges
Peter G.E. Kennedy
Peter G.E. Kennedy
Published February 15, 2004
Citation Information: J Clin Invest. 2004;113(4):496-504. https://doi.org/10.1172/JCI21052.
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Science in Medicine

Human African trypanosomiasis of the CNS: current issues and challenges

Abstract

Human African trypanosomiasis (HAT), also known as sleeping sickness, is a major cause of mortality and morbidity in sub-Saharan Africa. Current therapy with melarsoprol for CNS HAT has unacceptable side-effects with an overall mortality of 5%. This review discusses the issues of diagnosis and staging of CNS disease, its neuropathogenesis, and the possibility of new therapies for treating late-stage disease.

Authors

Peter G.E. Kennedy

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Colored scanning electron micrograph of Trypanosoma brucei in human bloo...
Colored scanning electron micrograph of Trypanosoma brucei in human blood. Image credit: Science Photo Library.