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Usage Information

Bateman domains and adenosine derivatives form a binding contract
Bruce E. Kemp
Bruce E. Kemp
Published January 15, 2004
Citation Information: J Clin Invest. 2004;113(2):182-184. https://doi.org/10.1172/JCI20846.
View: Text | PDF
Commentary

Bateman domains and adenosine derivatives form a binding contract

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Abstract

Conserved pairs of CBS sequence motifs (named after cystathionine β-synthase) found in a wide variety of proteins associate to form Bateman domains. A new study establishes that Bateman domains bind adenosyl compounds and regulate IMP dehydrogenase, CBS, chloride channels, and AMP-activated protein kinase. This discovery reveals how mutations in CBS sequences in these proteins cause hereditary diseases and provides a rich vista of conceptual opportunities for therapies in energy metabolism, obesity, diabetes, cancer, antivirals, and immunosuppression.

Authors

Bruce E. Kemp

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