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Usage Information

How do mutations in lamins A and C cause disease?
Howard J. Worman, Jean-Claude Courvalin
Howard J. Worman, Jean-Claude Courvalin
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How do mutations in lamins A and C cause disease?

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Abstract

Mutations in lamins A and C, nuclear intermediate-filament proteins in nearly all somatic cells, cause a variety of diseases that primarily affect striated muscle, adipocytes, or peripheral nerves or cause features of premature aging. Two new studies use lamin A/C–deficient mice, which develop striated muscle disease, as a model to investigate pathogenic mechanisms. These reports provide evidence for a stepwise process in which mechanically stressed cells first develop chromatin and nuclear envelope damage and then develop secondary alterations in the transcriptional activation of genes in adaptive and protective pathways.

Authors

Howard J. Worman, Jean-Claude Courvalin

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Usage data is cumulative from October 2025 through October 2026.

Usage JCI PMC
Text version 1,047 130
PDF 431 15
Figure 372 0
Table 139 0
Citation downloads 309 0
Totals 2,298 145
Total Views 2,443
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ISSN: 0021-9738 (print), 1558-8238 (online)

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