Bmi1, stem cells, and senescence regulation
In-Kyung Park, … , Sean J. Morrison, Michael F. Clarke
In-Kyung Park, … , Sean J. Morrison, Michael F. Clarke
Published January 15, 2004
Citation Information: J Clin Invest. 2004;113(2):175-179. https://doi.org/10.1172/JCI20800.
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Category: Perspective Series

Bmi1, stem cells, and senescence regulation

Abstract

Stem cells generate the differentiated cell types within many organs throughout the lifespan of an organism and are thus ultimately responsible for the longevity of multicellular organisms. Therefore, senescence of stem cells must be prevented. Bmi1 is required for the maintenance of adult stem cells in some tissues partly because it represses genes that induce cellular senescence and cell death.

Authors

In-Kyung Park, Sean J. Morrison, Michael F. Clarke

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Figure 1

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Postulated Bmi1 targets. Extrinsic signals for a stem cell to self-renew...
Postulated Bmi1 targets. Extrinsic signals for a stem cell to self-renew result in elevation of the Bmi1 level in stem cells. This allows repression of various genes including the Ink4a locus genes, p16Ink4a and p19Arf, and possibly activation, via indirect mechanisms, of some genes including telomerase, apoptosis inhibitor-6 (Ai6), and platelet-activating factor acetylhydrolase (PAF-AHγ). These genes are likely play a role in stem cell fate decisions including self-renewal and differentiation. *Sites of frequent mutations associated with cancer. TJP, tight junction protein. RDC1, chemokine orphan receptor 1.