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Usage Information

A radical explanation for glucose-induced β cell dysfunction
Michael Brownlee
Michael Brownlee
Published December 15, 2003
Citation Information: J Clin Invest. 2003;112(12):1788-1790. https://doi.org/10.1172/JCI20501.
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Commentary

A radical explanation for glucose-induced β cell dysfunction

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Abstract

The development of type 2 diabetes requires impaired β cell function. Hyperglycemia itself causes further decreases in glucose-stimulated insulin secretion. A new study demonstrates that hyperglycemia-induced mitochondrial superoxide production activates uncoupling protein 2, which decreases the ATP/ADP ratio and thus reduces the insulin-secretory response. These data suggest that pharmacologic inhibition of mitochondrial superoxide overproduction in β cells exposed to hyperglycemia could prevent a positive feed-forward loop of glucotoxicity that drives impaired glucose tolerance toward frank type 2 diabete

Authors

Michael Brownlee

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
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PDF 66 31
Figure 180 0
Citation downloads 63 0
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