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Usage Information

LRP: a bright beacon at the blood-brain barrier
Joachim Herz
Joachim Herz
Published November 15, 2003
Citation Information: J Clin Invest. 2003;112(10):1483-1485. https://doi.org/10.1172/JCI20337.
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Commentary

LRP: a bright beacon at the blood-brain barrier

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Abstract

Ever more unexpected roles for the LDL receptor gene family in a variety of cellular signaling pathways continue to emerge. Three recent studies now add another function to this collection. By interacting with active tissue-type plasminogen activator, LDL receptor–related protein appears to control permeability of the blood-brain barrier, vascular tone, and the expression of MMPs. All of these parameters impact upon postischemic infarct size following stroke. These novel findings are discussed in the context of known mechanisms of signaling by the LDL receptor family.

Authors

Joachim Herz

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Usage data is cumulative from August 2024 through August 2025.

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PDF 65 19
Figure 52 1
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Total Views 788
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