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Usage Information

Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections
Morten Hentzer, Michael Givskov
Morten Hentzer, Michael Givskov
Published November 1, 2003
Citation Information: J Clin Invest. 2003;112(9):1300-1307. https://doi.org/10.1172/JCI20074.
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Perspective Series

Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections

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Abstract

Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. A major concern with this approach is the frequently observed development of resistance to antimicrobial compounds. The discovery of bacterial-communication systems (quorum-sensing systems), which orchestrate important temporal events during the infection process, has afforded a novel opportunity to ameliorate bacterial infection by means other than growth inhibition. Compounds able to override bacterial signaling are present in nature. Herein we discuss the known signaling mechanisms and potential antipathogenic drugs that specifically target quorum-sensing systems in a manner unlikely to pose a selective pressure for the development of resistant mutants.

Authors

Morten Hentzer, Michael Givskov

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Usage data is cumulative from February 2022 through February 2023.

Usage JCI PMC
Text version 1,927 1,153
PDF 188 64
Figure 207 5
Citation downloads 67 0
Totals 2,389 1,222
Total Views 3,611
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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