Long QT syndrome: novel insights into the mechanisms of cardiac arrhythmias

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Abstract

The congenital long QT syndrome is a rare disorder in which mutation carriers are at risk for polymorphic ventricular tachycardia and/or sudden cardiac death. Discovery and analysis of gene mutations associated with variants of this disorder have provided novel insight into mechanisms of cardiac arrhythmia and have raised the possibility of mutation-specific therapeutic intervention.

Authors

Robert S. Kass, Arthur J. Moss