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Usage Information

15-deoxy-Δ12,14-PGJ2: endogenous PPARγ ligand or minor eicosanoid degradation product?
William S. Powell
William S. Powell
Published September 15, 2003
Citation Information: J Clin Invest. 2003;112(6):828-830. https://doi.org/10.1172/JCI19796.
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Commentary

15-deoxy-Δ12,14-PGJ2: endogenous PPARγ ligand or minor eicosanoid degradation product?

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Abstract

15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) affects gene transcription by activating PPARγ and by covalent addition to transcription factors and signaling molecules, However, it is not known whether the high concentrations of 15d-PGJ2 required for these responses are consistent with physiological levels. A new study suggests that in vivo 15d-PGJ2 levels are actually several orders of magnitude below the levels required to induce many of the biological effects attributed to this molecule.

Authors

William S. Powell

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