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Usage Information

Therapeutic B cell depletion identifies immunoregulatory networks
Carolina M. Polonio, Francisco J. Quintana
Carolina M. Polonio, Francisco J. Quintana
Published June 2, 2025
Citation Information: J Clin Invest. 2025;135(11):e189442. https://doi.org/10.1172/JCI189442.
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Commentary

Therapeutic B cell depletion identifies immunoregulatory networks

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Abstract

B cell depletion is a highly effective therapy in multiple sclerosis (MS), reducing inflammation and restoring immune balance. In this issue of the JCI, Wei et al. used single-cell RNA-Seq and flow cytometry, identifying the comprehensive effects of B cell depletion on the immune response, including an increase in antiinflammatory cerebrospinal fluid macrophages and elevated TNF-α expression by peripheral CD16+ monocytes. The authors also detected shifts in T cell populations that resulted in reduced myelin-reactive CD4+ T cells and the expansion of TIGIT+ Tregs. The findings uncover immunoregulatory mechanisms and suggest therapeutic strategies for MS and other autoimmune disorders.

Authors

Carolina M. Polonio, Francisco J. Quintana

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Usage data is cumulative from June 2025 through July 2025.

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