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T cell apoptosis and reactive oxygen species
David A. Hildeman, … , John Kappler, Philippa Marrack
David A. Hildeman, … , John Kappler, Philippa Marrack
Published March 1, 2003
Citation Information: J Clin Invest. 2003;111(5):575-581. https://doi.org/10.1172/JCI18007.
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Perspective

T cell apoptosis and reactive oxygen species

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Abstract

Authors

David A. Hildeman, Thomas Mitchell, John Kappler, Philippa Marrack

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Figure 1

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Graph of the kinetics of the T cell response to antigenic stimulation in...
Graph of the kinetics of the T cell response to antigenic stimulation in vivo. Following stimulation with antigen, antigen-specific T cells proliferate vigorously to reach peak numbers during the expansion phase. They then decline in number rapidly, a process referred to as the contraction phase. Importantly, both the peak-expansion phase and the contraction phase can be independently modulated by stimulators of innate immunity (adjuvants) (53, 54).

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