The nociceptin/orphanin FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia
Garth T. Whiteside, … , Sandra K. Willsie, Stephen C. Harris
Garth T. Whiteside, … , Sandra K. Willsie, Stephen C. Harris
Published October 26, 2023
Citation Information: J Clin Invest. 2024;134(1):e171172. https://doi.org/10.1172/JCI171172.
View: Text | PDF
Research Letter Neuroscience

The nociceptin/orphanin FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia

Abstract

Authors

Garth T. Whiteside, Donald J. Kyle, Ram P. Kapil, Alessandra Cipriano, Ellie He, Mingyan Zhou, Manjunath S. Shet, Michele Hummel, Terri Knappenberger, Kazuya Fukumura, Yoshiyuki Matsuo, Masahiro Uehira, Shuichi Hiroyama, Nozomi Takai, Sandra K. Willsie, Stephen C. Harris

×

Figure 1

Sunobinop pharmacokinetics in rat and human, lack of reward and lack of effect on learning and memory in rats, and effects on sleep parameters in rats and human patients.

Options: View larger image (or click on image) Download as PowerPoint
Sunobinop pharmacokinetics in rat and human, lack of reward and lack of ...
(A) Pharmacokinetic profile in rats after oral dosing. (B) Effect on sleep stages as measured by EEG in WT and NOP-KO rats. (C and D) Effect on learning and memory and reward in rats as measured by Morris water maze and conditioned place preference. (E) Pharmacokinetic profile in healthy male human subjects after oral dosing. (F–H) Polysomnography results in patients with insomnia disorder: (F) sleep parameters, subjective sleep quality (sSQ) (G), and sleep architecture (H). NAW, number of awakenings. Data are represented as means ± SEM (A–C and H), means ± SD (E), and median ± interquartile range (D, F, and G), with dotted lines (D) and error bars (F and G) showing 10th to 90th percentiles, outliers shown, and plus signs indicating the mean (F and G). Data points in H represent raw data. *P ≤ 0.05, ANOVA (D); t test (all others).