Active transcription in the vascular bed characterizes rapid progression in idiopathic pulmonary fibrosis
Nirmal S. Sharma, … , Camilla Margaroli, Amit Gaggar
Nirmal S. Sharma, … , Camilla Margaroli, Amit Gaggar
Published June 29, 2023
Citation Information: J Clin Invest. 2023;133(16):e165976. https://doi.org/10.1172/JCI165976.
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Research Letter Pulmonology Vascular biology

Active transcription in the vascular bed characterizes rapid progression in idiopathic pulmonary fibrosis

Abstract

Authors

Nirmal S. Sharma, Kapil Patel, Ezgi Sari, Shruti Shankar, Maria G. Gastanadui, Diego Moncada-Giraldo, Yixel Soto-Vazquez, Delores Stacks, Louise Hecker, Kevin Dsouza, Mudassir Banday, Edward O’Neill, Paul Benson, Gregory Payne, Camilla Margaroli, Amit Gaggar

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Figure 1

Transcriptional profile of the IPF lung shows unique signatures.

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Transcriptional profile of the IPF lung shows unique signatures. (A) Lun...
(A) Lung biopsies from patients with IPF characterized as SP or RP stained with H&E (left) or Trichrome (right). Scale bar: 250 μm. (B) Immunofluorescence staining and ROI selection. Scale bar: 500 μm. (C) Differential gene expression analysis (SP = 5 patients; RP = 4 patients). (D) Immunofluorescence staining and ROI selection for vascular bed. Scale bar: 500 μm. (E and F) Number of upregulated genes. (G) Differential gene expression analysis of vascular bed. (H) Unique upregulated genes in the RP vascular bed. Significance for differential gene expression: log2 fold change of 1 or –1, P = 0.05.