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The TSH receptor reveals itself
Terry Davies, … , Russell Marians, Rauf Latif
Terry Davies, … , Russell Marians, Rauf Latif
Published July 15, 2002
Citation Information: J Clin Invest. 2002;110(2):161-164. https://doi.org/10.1172/JCI16234.
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Commentary Immunology

The TSH receptor reveals itself

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Abstract

Commentary

Authors

Terry Davies, Russell Marians, Rauf Latif

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Figure 1

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Two possible structural configurations of TSH receptor. (a) The uncleave...
Two possible structural configurations of TSH receptor. (a) The uncleaved receptor is shown with a “buried” structure. The ectodomain and transmembrane interactions result in a “closed” conformation (connecting dotted lines). (b) Cleavage may induce an “open” conformation, a step that is thought to be a precondition for subsequent changes in receptor localization and activity, as described in the text and shown in Figure 2. This figure is adapted from ref. 25 with permission.

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